In addition, there is a change in the structure of cell membranes due to lipid degradation. The active metabolites of the drug form covalent bonds with hepatocyte proteins, which provokes the denaturation of the latter. The effect of paracetamol is predominantly hepatotoxic. It is also necessary to take into account the risk of accidental ingestion of tablets by children if the drug is stored in the public domain. Elderly people and patients with mental disorders are able to confuse the drug with those medications that they take constantly. Sometimes paracetamol poisoning occurs as a result of mistakenly drinking the drug. If the signs of pathology were noticed in a timely manner, it does not go beyond a mild degree.
When the medication is taken for more than 2-3 days, its concentration in the body becomes toxic (150-250 mcg / ml). A decrease in the functional capabilities of the organ, which arose as a result of disease or treatment with inducers of liver enzymes, leads to a slowdown in the metabolism of paracetamol and its accumulation. Such exotoxicoses occur relatively easily and do not lead to serious consequences. Pathology also develops in patients who do not observe the minimum required interval between doses of the drug, which should be equal to four hours.
Symptoms occur when using more than 2 tablets (1000 mg) at a time or more than 8 tablets (4 grams) per day. In elderly people, para-aminophenol intoxication is rarely diagnosed. Paracetamol poisoning as a way of voluntary retirement is usually chosen by teenagers, young women, and middle-aged men. This becomes possible in the following cases: The most common mechanism of pathology is the deliberate use of the drug in a dose many times higher than the therapeutic one. The risk group is children, people with reduced liver function, patients who prefer to avoid visiting a doctor and taking medications on their own, adolescents who are prone to suicidal attempts. Today, the share of drug poisoning with antipyretic substances accounts for about 12% of the total number of hospitalizations. Paracetamol poisoning is common among residents of Denmark, France, Great Britain, Norway. T39.1 Poisoning with 4-aminophenol derivatives General information
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